Can uric acid blood levels in renal transplant recipients predict allograft outcome?. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Isakov, Ofer; Patibandla, Bhanu K.; Shwartz, Doron; Mor, Eytan; Christopher, Kenneth B.; Hod, Tammy
• Is Part Of: Renal failure. Volume 43:Issue 1(2021)
• Page Start: 1240
• Page End: 1249
• Publication Date: 2021-01-01
• Subjects: Hyperuricemia -- renal allograft function -- renal allograft survival -- mortality; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.1080/0886022X.2021.1969246
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Background: Hyperuricemia is common after renal transplantation, especially in those receiving calcineurin inhibitors. Little, however, is known about the relationship between uric acid (UA) levels and allograft outcome. Methods: We conducted a retrospective single-center analysis ( N = 368) in order to assess UA blood levels post-transplant association with allograft outcome. For this study, a median serum UA level of all measured UA levels from 1 month to 1 year post renal transplantation was calculated. Results: Patients were divided into 2 groups based on the median UA level measured between 1 and 12 months post-transplant. Those with median UA level ≥ 7 and ≥ 6 mg/dL ( N = 164) versus median UA level < 7 and < 6 mg/dL for men and women respectively ( N = 204) had lower GFR values at 1, 3 and 5 years posttransplant (mean GFR ± SD of 43.4 ± 20.6 and 58 ± 19.9 at 3 years post-transplant, p < 0.001). In multivariate models, UA levels were no longer significantly associated with renal allograft function. In a multivariate cox proportional hazard model, UA level was found to be independently associated with increased risk for death-censored graft loss (HR of 1.3, 95% CI 1.0–1.7, p < 0.05 for every increase of 1 mg/dL in UA level). Conclusion: Hyperuricemia was found to be associated with increased death- censored graft loss but not with allograft function. Increased UA levels were not found to be an independent predictor of long-term allograft function despite the known association of hyperuricemia with the progression of cardiovascular and renal disease.