An Evolutionary Perspective on Yeast Mating-Type Switching. Issue 1 (1st May 2017)
- Record Type:
- Journal Article
- Title:
- An Evolutionary Perspective on Yeast Mating-Type Switching. Issue 1 (1st May 2017)
- Main Title:
- An Evolutionary Perspective on Yeast Mating-Type Switching
- Authors:
- Hanson, Sara J
Wolfe, Kenneth H - Abstract:
- Abstract: Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved by two functionally similar but structurally distinct processes in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe . In both species, haploid cells possess one active and two silent copies of the mating-type locus (a three-cassette structure), the active locus is cleaved, and synthesis-dependent strand annealing is used to replace it with a copy of a silent locus encoding the opposite mating-type information. Each species has its own set of components responsible for regulating these processes. In this review, we summarize knowledge about the function and evolution of mating-type switching components in these species, including mechanisms of heterochromatin formation, MAT locus cleavage, donor bias, lineage tracking, and environmental regulation of switching. We compare switching in these well-studied species to others such as Kluyveromyces lactis and the methylotrophic yeasts Ogataea polymorpha and Komagataella phaffii . We focus on some key questions: Which cells switch mating type? What molecular apparatus is required for switching? Where did it come from? And what is the evolutionary purpose of switching?
- Is Part Of:
- Genetics. Volume 206:Issue 1(2017)
- Journal:
- Genetics
- Issue:
- Volume 206:Issue 1(2017)
- Issue Display:
- Volume 206, Issue 1 (2017)
- Year:
- 2017
- Volume:
- 206
- Issue:
- 1
- Issue Sort Value:
- 2017-0206-0001-0000
- Page Start:
- 9
- Page End:
- 32
- Publication Date:
- 2017-05-01
- Subjects:
- mating-type switching -- yeast genetics -- evolution -- sporulation -- homothallism
Genetics -- Periodicals
576.5 - Journal URLs:
- http://www.oxfordjournals.org/ ↗
- DOI:
- 10.1534/genetics.117.202036 ↗
- Languages:
- English
- ISSNs:
- 0016-6731
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 25281.xml