Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment. Issue 12 (1st October 2020)

• Record Type: Journal Article
• Authors: Kamintsky, Lyna; Beyea, Steven D; Fisk, John D; Hashmi, Javeria A; Omisade, Antonina; Calkin, Cynthia; Bardouille, Tim; Bowen, Chris; Quraan, Maher; Mitnitski, Arnold; Matheson, Kara; Friedman, Alon; Hanly, John G
• Is Part Of: Annals of the rheumatic diseases. Volume 79:Issue 12(2020)
• Page Start: 1580
• Page End: 1587
• Publication Date: 2020-10-01
• Subjects: systemic lupus erythematosus -- magnetic resonance imaging -- autoimmunity -- Blood-brain barrier -- cognitive impairment; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-218004
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To examine the association between blood-brain barrier (BBB) integrity, brain volume and cognitive dysfunction in adult patients with systemic lupus erythematosus (SLE). Methods: A total of 65 ambulatory patients with SLE and 9 healthy controls underwent dynamic contrast-enhanced MRI scanning, for quantitative assessment of BBB permeability. Volumetric data were extracted using the VolBrain pipeline. Global cognitive function was evaluated using a screening battery consisting of tasks falling into five broad cognitive domains, and was compared between patients with normal versus extensive BBB leakage. Results: Patients with SLE had significantly higher levels of BBB leakage compared with controls (p=0.04). Extensive BBB leakage (affecting over >9% of brain volume) was identified only in patients with SLE (16/65; 24.6%), who also had smaller right and left cerebral grey matter volumes compared with controls (p=0.04). Extensive BBB leakage was associated with lower global cognitive scores (p=0.02), and with the presence of impairment on one or more cognitive tasks (p=0.01). Conclusion: Our findings provide evidence for a link between extensive BBB leakage and changes in both brain structure and cognitive function in patients with SLE. Future studies should investigate the mechanisms underlying BBB-mediated cognitive impairment, validate the diagnostic utility of BBB imaging, and determine the potential of targeting the BBB as a therapeutic strategy in patients with SLE.