Plegia to walking: AHSCBMT in severe NMOSD relapse. Issue 2 (26th October 2020)

• Record Type: Journal Article
• Authors: Carlisle, Nicola; Hari, Parameswaran; Brod, Staley
• Is Part Of: BMJ neurology open. Volume 2:Issue 2(2020)
• Publication Date: 2020-10-26
• Subjects: neuroimmunology; Neurology -- Periodicals; 616.8
• DOI: 10.1136/bmjno-2020-000073
• Languages: English
• ISSNs: 2632-6140

Abstract

Abstract : Objectives: Neuromyelitis optica is a devastating, relapsing, inflammatory, autoimmune disorder characterised in large part by attacks of optic neuritis and transverse myelitis causing blindness and plegia in many patients. Eighty-three per cent of patients with transverse myelitic attacks and 67% of patients with optic neuritis attacks have no or a partial recovery. Methods: Results from The European Group for Blood and Marrow Transplantation Autoimmune Diseases Working Party imply failure of autologous haematopoietic stem cell bone marrow transplantation. Results and conclusion: We present a case that despite eventual relapse, made a remarkable functional recovery after bone marrow transplantation which may justify bone marrow transplantation in severe cases.