Gene Conversion Facilitates Adaptive Evolution on Rugged Fitness Landscapes. Issue 4 (3rd October 2017)

• Record Type: Journal Article
• Authors: Bittihn, Philip; Tsimring, Lev S
• Is Part Of: Genetics. Volume 207:Issue 4(2017)
• Page Start: 1577
• Page End: 1589
• Publication Date: 2017-10-03
• Subjects: gene conversion -- gene duplication -- pseudogenes -- fitness landscape -- adaptive evolution; Genetics -- Periodicals; 576.5
• DOI: 10.1534/genetics.117.300350
• Languages: English
• ISSNs: 0016-6731

Abstract

Abstract: An important question in evolutionary theory is how adaptation might be hindered on a rugged fitness landscape in the presence of strong selection that.. Gene conversion is a ubiquitous phenomenon that leads to the exchange of genetic information between homologous DNA regions and maintains coevolving multi-gene families in most prokaryotic and eukaryotic organisms. In this paper, we study its implications for the evolution of a single functional gene with a silenced duplicate, using two different models of evolution on rugged fitness landscapes. Our analytical and numerical results show that, by helping to circumvent valleys of low fitness, gene conversion with a passive duplicate gene can cause a significant speedup of adaptation, which depends nontrivially on the frequency of gene conversion and the structure of the landscape. We find that stochastic effects due to finite population sizes further increase the likelihood of exploiting this evolutionary pathway. A universal feature appearing in both deterministic and stochastic analysis of our models is the existence of an optimal gene conversion rate, which maximizes the speed of adaptation. Our results reveal the potential for duplicate genes to act as a "scratch paper" that frees evolution from being limited to strictly beneficial mutations in strongly selective environments.