Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication. (2nd August 2021)

• Record Type: Journal Article
• Authors: Gordon, Claire L; Smibert, Olivia C; Holmes, Natasha E; Chua, Kyra Y L; Rose, Morgan; Drewett, George; James, Fiona; Mouhtouris, Effie; Nguyen, Thi H O; Zhang, Wuji; Kedzierski, Lukasz; Rowntree, Louise C; Chua, Brendon Y; Caly, Leon; Catton, Mike G; Druce, Julian; Sait, Michelle; Seemann, Torsten; Sherry, Norelle L; Howden, Benjamin P; Kedzierska, Katherine; Kwong, Jason C; Trubiano, Jason A
• Is Part Of: Open forum infectious diseases. Volume 8:Number 9(2021)
• Publication Date: 2021-08-02
• Subjects: cellular immunity -- COVID-19 -- humoral immunity -- immunocompromise -- lymphoma -- SARS-CoV-2; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab359
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR + /CD38 + activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2–specific antibody responses were absent and SARS-CoV-2–specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses. Abstract : We describe defects in severe acute respiratory syndrome coronavirus 2–specific immune responses and persistent viral replication in a patient with lymphoma. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.