Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study. (27th November 2020)

• Record Type: Journal Article
• Authors: Pastor-Barriuso, Roberto; Pérez-Gómez, Beatriz; Hernán, Miguel A; Pérez-Olmeda, Mayte; Yotti, Raquel; Oteo-Iglesias, Jesús; Sanmartín, Jose L; León-Gómez, Inmaculada; Fernández-García, Aurora; Fernández-Navarro, Pablo; Cruz, Israel; Martín, Mariano; Delgado-Sanz, Concepción; Fernández de Larrea, Nerea; León Paniagua, Jose; Muñoz-Montalvo, Juan F; Blanco, Faustino; Larrauri, Amparo; Pollán, Marina
• Other Names: author non-byline.; Aparicio Azcárraga Pilar author non-byline.; Blanco Faustino author non-byline.; Gutiérrez Fernández Rodrigo author non-byline.; Martín Mariano author non-byline.; Mezcua Navarro Saturnino author non-byline.; Molina Marta author non-byline.; Muñoz-Montalvo Juan F author non-byline.; Salinero Hernández Matías author non-byline.; Sanmartín Jose L author non-byline.; Cuenca-Estrella Manuel author non-byline.; León Paniagua José author non-byline.; Yotti Raquel author non-byline.; Delgado-Sanz Concepción author non-byline.; Fernández de Larrea Nerea author non-byline.; Fernández-Navarro Pablo author non-byline.; Gómez-Barroso Diana author non-byline.; Larrauri Amparo author non-byline.; León-Gómez Inmaculada author non-byline.; Pastor-Barriuso Roberto author non-byline.; Pérez-Gómez Beatriz author non-byline.; Pollán Marina author non-byline.; Avellón Ana author non-byline.; Fedele Giovanni author non-byline.; Fernández-García Aurora author non-byline.; Oteo Iglesias Jesús author non-byline.; Pérez Olmeda María Teresa author non-byline.; Cruz Israel author non-byline.; Fernández Martínez Maria Elena author non-byline.; Rodríguez-Cabrera Francisco D author non-byline.; Hernán Miguel A author non-byline.; Padrones Fernández Susana author non-byline.; Rumbao Aguirre José Manuel author non-byline.; Navarro Marí José M author non-byline.; Palop Borrás Begoña author non-byline.; Pérez Jiménez Ana Belén author non-byline.; Rodríguez-Iglesias Manuel author non-byline.; Calvo Gascón Ana María author non-byline.; Lou Alcaine María Luz author non-byline.; Donate Suárez Ignacio author non-byline.; Suárez Álvarez Oscar author non-byline.; Rodríguez Pérez Mercedes author non-byline.; Cases Sanchís Margarita author non-byline.; Villafáfila Gomila Carlos Javier author non-byline.; Carbo Saladrigas Lluis author non-byline.; Hurtado Fernández Adoración author non-byline.; Oliver Antonio author non-byline.; Castro Feliciano Elías author non-byline.; González Quintana María Noemí author non-byline.; Barrasa Fernández José María author non-byline.; Hernández Betancor María Araceli author non-byline.; Hernández Febles Melisa author non-byline.; Martín Martín Leopoldo author non-byline.; López López Luis-Mariano author non-byline.; Ugarte Miota Teresa author non-byline.; De Benito Población Inés author non-byline.; Celada Pérez María Sagrario author non-byline.; Vallés Fernández María Natalia author non-byline.; Maté Enríquez Tomás author non-byline.; Villa Arranz Miguel author non-byline.; Domínguez-Gil González Marta author non-byline.; Fernández-Natal Isabel author non-byline.; Megías Lobón Gregoria author non-byline.; Muñoz Bellido Juan Luis author non-byline.; Ciruela Pilar author non-byline.; Mas i Casals Ariadna author non-byline.; Doladé Botías Maria author non-byline.; Marcos Maeso M Angeles author non-byline.; Pérez del Campo Dúnia author non-byline.; Félix de Castro Antonio author non-byline.; Limón Ramírez Ramón author non-byline.; Elías Retamosa Maria Francisca author non-byline.; Rubio González Manuela author non-byline.; Blanco Lobeiras María Sinda author non-byline.; Fuentes Losada Alberto author non-byline.; Aguilera Antonio author non-byline.; Bou German author non-byline.; Caro Yolanda author non-byline.; Marauri Noemí author non-byline.; Soria Blanco Luis Miguel author non-byline.; del Cura González Isabel author non-byline.; Hernández Pascual Montserrat author non-byline.; Alonso Fernández Roberto author non-byline.; Merino-Amador Paloma author non-byline.; Cabrera Castro Natalia author non-byline.; Tomás Lizcano Aurora author non-byline.; Ramírez Almagro Cristóbal author non-byline.; Segovia Hernández Manuel author non-byline.; Ascunce Elizaga Nieves author non-byline.; Ederra Sanz María author non-byline.; Ezpeleta Baquedano Carmen author non-byline.; Bustinduy Bascaran Ana author non-byline.; Iglesias Tamayo Susana author non-byline.; Elorduy Otazua Luis author non-byline.; Benarroch Benarroch Rebeca author non-byline.; Lopera Flores Jesús author non-byline.; Vázquez de la Villa Antonia author non-byline.;
• Is Part Of: BMJ. Volume 371(2020)
• Publication Date: 2020-11-27
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.m4509
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract: Objective: To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes. Design: Nationwide seroepidemiological study. Setting: First wave of covid-19 pandemic in Spain. Participants: Community dwelling individuals of all ages. Main outcome measures: The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61 098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020. Results: The overall infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24 778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more. Conclusion: The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza.