A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans. Issue 3 (15th January 2015)

• Record Type: Journal Article
• Authors: Varshney, Neha; Schaekel, Alida; Singha, Rima; Chakraborty, Tanmoy; van Wijlick, Lasse; Ernst, Joachim F; Sanyal, Kaustuv
• Is Part Of: Genetics. Volume 199:Issue 3(2015)
• Page Start: 671
• Page End: 674
• Publication Date: 2015-01-15
• Subjects: kinase -- Sch9 -- centromere -- chromosome segregation -- kinetochore; Genetics -- Periodicals; 576.5
• DOI: 10.1534/genetics.114.173542
• Languages: English
• ISSNs: 0016-6731

Abstract

Abstract: The AGC kinase Sch9 regulates filamentation in Candida albicans . Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae . Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.