Cervicovaginal cellular angiofibroma. Issue 7 (16th July 2020)

• Record Type: Journal Article
• Authors: Van Mulders, Sarah; Faes, Ellen; Broeckx, Glenn; Jacquemyn, Yves
• Is Part Of: BMJ case reports. Volume 13:Issue 7(2020)
• Publication Date: 2020-07-16
• Subjects: obstetrics and gynaecology -- pathology; Medicine -- Case studies -- Periodicals; 610.5
• DOI: 10.1136/bcr-2020-235241
• Languages: English
• ISSNs: 1757-790X

Abstract

Abstract : Cellular angiofibroma is a rare type of benign mesenchymal tumour that arises mostly in middle-aged women. It needs to be distinguished from other neoplasms and has a predilection for the vulvovaginal region. To our knowledge, this is the first case of a cervical cellular angiofibroma. A 34-year-old nulligravid woman was referred with a large mass bulging in the fornix posterior. Ultrasound scanning and MRI showed a large solid mass projecting in the pouch of Douglas. Laparoscopic surgical excision was performed. Histopathological examination showed a well-demarcated, unencapsulated tumour, consisting of short fascicles of spindle cells in-between thick-walled medium-sized vessels. On immunohistochemistry, there was strong reactivity with antibodies against CD34 and oestrogen receptor. Angiofibromas are benign mesenchymal tumours mostly occurring in middle-aged women. They can cause abnormal swelling and uterine bleeding and need to be distinguished from other (malignant) neoplasms.