Improving the Power of GWAS and Avoiding Confounding from Population Stratification with PC-Select. Issue 3 (1st July 2014)

• Record Type: Journal Article
• Authors: Tucker, George; Price, Alkes L; Berger, Bonnie
• Is Part Of: Genetics. Volume 197:Issue 3(2014)
• Page Start: 1045
• Page End: 1049
• Publication Date: 2014-07-01
• Subjects: mixed models -- population stratification -- GWAS; Genetics -- Periodicals; 576.5
• DOI: 10.1534/genetics.114.164285
• Languages: English
• ISSNs: 0016-6731

Abstract

Abstract: Using a reduced subset of SNPs in a linear mixed model can improve power for genome-wide association studies, yet this can result in insufficient correction for population stratification. We propose a hybrid approach using principal components that does not inflate statistics in the presence of population stratification and improves power over standard linear mixed models.