Effects of sleep quality on non-alcoholic fatty liver disease: a cross-sectional survey. Issue 10 (29th October 2020)

• Record Type: Journal Article
• Authors: Takahashi, Atsushi; Anzai, Yukio; Kuroda, Masahito; Kokubun, Masae; Kondo, Yuichiro; Ogata, Takashi; Fujita, Masashi; Hayashi, Manabu; Imaizumi, Hiromichi; Abe, Kazumichi; Tanji, Nobuo; Ohira, Hiromasa
• Is Part Of: BMJ open. Volume 10:Issue 10(2020)
• Publication Date: 2020-10-29
• Subjects: gastroenterology -- hepatobiliary disease -- sleep medicine; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-039947
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Background: The effects of sleep quality on the risk of developing non-alcoholic fatty liver disease (NAFLD) remain uncertain. The purpose of this study was to clarify the association between sleep quality and NAFLD. Methods: The data of 4828 participants who underwent health check-ups at four hospitals were analysed. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI), which comprised seven elements scored from 0 to 3. The global PSQI score and the score for each element were compared between NAFLD and non-NAFLD groups separately by sex. Logistic regression analysis was performed to determine the association between NAFLD and each PSQI score. Results: In both men and women, the mean PSQI score for sleep medication use was significantly higher in non-NAFLD than in NAFLD. With regard to sleep medication use in men, the OR (95% CI) for NAFLD was lower with a score of 3 (OR 0.60, 95% CI 0.38–0.95) than with a score of 0 on multivariate logistic regression analysis adjusted for age, smoking habits and physical activity. The OR for NAFLD based on daytime dysfunction was also higher with a score of 3 than with a score of 0 in both men (OR 2.82, 95% CI 1.39–5.75) and women (OR 2.08, 95% CI 1.10–3.92). After adjustment for body mass index, the sleep latency scores in men and daytime dysfunction in women were associated with NAFLD. Conclusion: Sleep quality was associated with NAFLD, and there were sex differences.