Gene-level quantitative trait mapping in Caenorhabditis elegans. Issue 2 (23rd January 2021)

• Record Type: Journal Article
• Authors: Noble, Luke M; Rockman, Matthew V; Teotónio, Henrique
• Editors: Kim, Y
• Is Part Of: G3. Volume 11:Issue 2(2021)
• Publication Date: 2021-01-23
• Subjects: genetic architecture -- experimental evolution -- quantitative trait -- complex trait -- QTL -- MPP -- Multiparental Populations -- Multiparent Advanced Generation Inter-Cross (MAGIC); Genetics -- Research -- Periodicals; Genomics -- Periodicals; Genetics; Genomics; Genes; Genetics -- Research; Genomics; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 572.8
• DOI: 10.1093/g3journal/jkaa061
• Languages: English
• ISSNs: 2160-1836

Abstract

Abstract: The Caenorhabditis elegans multiparental experimental evolution (CeMEE) panel is a collection of genome-sequenced, cryopreserved recombinant inbred lines useful for mapping the evolution and genetic basis of quantitative traits. We have expanded the resource with new lines and new populations, and here report the genotype and haplotype composition of CeMEE version 2, including a large set of putative de novo mutations, and updated additive and epistatic mapping simulations. Additive quantitative trait loci explaining 4% of trait variance are detected with >80% power, and the median detection interval approaches single-gene resolution on the highly recombinant chromosome arms. Although CeMEE populations are derived from a long-term evolution experiment, genetic structure is dominated by variation present in the ancestral population.