The possible role of methylglyoxal metabolism in cancer. (1st January 2021)

• Record Type: Journal Article
• Authors: Alfarouk, Khalid O.; Alqahtani, Saad S.; Alshahrani, Saeed; Morgenstern, Jakob; Supuran, Claudiu T.; Reshkin, Stephan J.
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 36:Number 1(2021)
• Page Start: 2010
• Page End: 2015
• Publication Date: 2021-01-01
• Subjects: Methylglyoxal -- cancer -- enzyme -- pH -- redox; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2021.1972994
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal (MG) one. This pathway helps maintain the redox state, and it might act as a phosphate sensor that monitors the intracellular phosphate levels. In this work, we discuss the biochemical step of the MG pathway and interrelate it with cancer.