Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis. (January 2022)

• Record Type: Journal Article
• Authors: Lv, Huizhen; Ai, Ding
• Is Part Of: Journal of molecular and cellular cardiology. Volume 162(2022)
• Page Start: 158
• Page End: 165
• Publication Date: 2022-01
• Subjects: Mechanical forces -- Mechanotransduction -- Hippo/YAP pathway -- Vascular homeostasis; AMOT Angiomotin -- ANKRD1 Ankyrin repeat domain 1 -- CCL2 CC-chemokine ligand 2 -- CTGF Connective tissue growth factor -- CAFs Cancer-associated fibroblasts -- CXCL1 C-X-C motif chemokine ligand 1 -- CYR61 Cysteine-rich angiogenic inducer 61 -- ECs Endothelial cells -- ECM Extracellular matrix -- EPS8 EGF receptor kinase substrate 8 -- F-actin Filamentous actin -- FAs Fcal adhesions -- HMVEC Human lung microvascular endothelial cells -- IL-1β Interleukin-1β -- IRF3 Interferon regulatory factor 3 -- JNK JUN N-terminal kinase -- LATS1/2 Large tumor suppressor 1/2 -- MAPK4 Mitogen-activated protein kinase 4 -- MLCK Myosin light chain kinase -- MLK1 Mgakaryoblastic leukemia factor-1 -- MSC Mesenchymal stem cells -- MST1/2 STE20-like protein kinase 1/2 -- PH Pulmonary hypertension -- ROCK Rho-associated protein kinase -- TAZ Transcriptional co-activator with PDZ-binding motif -- TBK1 Tank binding kinase-1 -- TEAD Transcriptional enhancer associate domain family members -- Thbs1 Trombospondin-1 -- TRAF6 Tumor necrosis factor receptor-associated factor 6 -- VEGF Vascular endothelial growth factor -- VSMCs Vascular smooth muscle cells -- YAP Yes-associated protein; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2021.09.007
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Cells are constantly exposed to various mechanical forces, including hydrostatic pressure, cyclic stretch, fluid shear stress, and extracellular matrix stiffness. Mechanical cues can be translated into the cell-specific transcriptional process by a cellular mechanic-transducer. Evidence suggests that mechanical signals assist activated intracellular signal transduction pathways and the relative phenotypic adaptation to coordinate cell behavior and disease appropriately. The Hippo/yes-associated protein (YAP) signaling pathway is regulated in response to numerous mechanical stimuli. It plays an important role in the mechanotransduction mechanism, which converts mechanical forces to cascades of molecular signaling to modulate gene expression. This review summarizes the recent findings relevant to the Hippo/YAP pathway-based mechanotransduction in cell behavior and maintaining blood vessels, as well as cardiovascular disease. Highlights: How the mechanical cues are sensed and transduced at the molecular level to regulate gene expression remained elusive. Hippo/YAP functioned as a mechanotransduction switch of mechanical forces, and translated them into transcriptional process. Hippo/YAP function as a mechanotransducer in cell behavior, blood vessels maintenance, and cardiovascular diseases.