Clinical and Microbiological Characteristics of Hospital-Acquired Methicillin-Resistant Staphylococcus aureus Bacteremia Caused by a Community-Associated PVL-Negative Strain. (16th August 2021)

• Record Type: Journal Article
• Authors: Lee, Yun Woo; Bae, Seongman; Yang, Eunmi; Chung, Hyemin; Kim, Eunsil; Jung, Jiwon; Kim, Min Jae; Chong, Yong Pil; Kim, Sung-Han; Choi, Sang-Ho; Lee, Sang-Oh; Kim, Yang Soo
• Is Part Of: Open forum infectious diseases. Volume 8:Number 9(2021)
• Publication Date: 2021-08-16
• Subjects: bacteremia -- hospital -- acquired infection -- methicillin -- resistant Staphylococcus aureus -- outcome -- Panton -- Valentine Leukocidin -- negative; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab424
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: ST72-SCC mec IV, a community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain in Korea, originated in the community and has been spreading in health care settings. Herein, we describe the clinical and microbiological characteristics of patients with hospital-acquired MRSA bacteremia (MRSAB) caused by community-associated strains. Methods: We analyzed hospital-acquired MRSAB cases caused by ST72-SCC mec IV using a prospective cohort of patients with SAB in a tertiary hospital in Korea from July 2008 to December 2018. We compared the clinical and microbiological characteristics of ST72-SCC mec IV with ST5-SCC mec II, a representative hospital-associated genotype strain. Results: Of the 1782 S. aureus bacteremia (SAB) cases, 628 (35.2%) were hospital-acquired MRSAB. Of the 628 isolates, 431 (68.6%) were ST5-SCC mec II and 152 (24.2%) were ST72-SCC mec IV. Patients with ST72-SCC mec IV were younger than those with ST5-SCC mec II and less likely to have a history of recent surgery, antibiotic treatment, nasal MRSA colonization, and central venous catheter placement. Compared with ST5-SCC mec II, ST72-SCC mec IV isolates were more likely to have vancomycin MICs ≤1.0 mg/L ( P < .001). Osteoarticular infection as the site of infection (7.2% [11/152] vs 1.4% [6/431]) was more common in patients with ST72-SCC mec IV. There were no significant differences in the rate of recurrence (≤90 days), persistent bacteremia (≥7 days), or 30- and 90-day mortality rates between the 2 groups. Conclusions: Osteoarticular infections were more prevalent in ST72-SCC mec IV MRSAB. Mortality rates between the ST72-SCC mec IV and ST5-SCC mec II groups were not significantly different.