Estimating Realized Heritability in Panmictic Populations. Issue 1 (1st January 2018)

• Record Type: Journal Article
• Authors: Lstibůrek, Milan; Bittner, Václav; Hodge, Gary R; Picek, Jan; Mackay, Trudy F C
• Is Part Of: Genetics. Volume 208:Issue 1(2018)
• Page Start: 89
• Page End: 95
• Publication Date: 2018-01-01
• Subjects: quantitative genetics -- Hardy-Weinberg equilibrium -- panmictic population; Genetics -- Periodicals; 576.5
• DOI: 10.1534/genetics.117.300508
• Languages: English
• ISSNs: 0016-6731

Abstract

Abstract: Narrow sense heritability ( h 2 ) is a key concept in quantitative genetics, as it expresses the proportion of the observed phenotypic variation that is transmissible from parents to offspring. h 2 determines the resemblance among relatives, and the rate of response to artificial and natural selection. Classical methods for estimating h 2 use random samples of individuals with known relatedness, as well as response to artificial selection, when it is called realized heritability. Here, we present a method for estimating realized h 2 based on a simple assessment of a random-mating population with no artificial manipulation of the population structure, and derive SE of the estimates. This method can be applied to arbitrary phenotypic segments of the population (for example, the top-ranking p parents and offspring), rather than random samples. It can thus be applied to nonpedigreed random mating populations, where relatedness is determined from molecular markers in the p selected parents and offspring, thus substantially saving on genotyping costs. Further, we assessed the method by stochastic simulations, and, as expected from the mathematical derivation, it provides unbiased estimates of h 2 . We compared our approach to the regression and maximum-likelihood approaches utilizing Galton's dataset on human heights, and all three methods provided identical results.