Elevated Placental microRNA-155 Is a Biomarker of a Preeclamptic Subtype. Issue 2 (15th December 2022)

• Record Type: Journal Article
• Authors: Wang, Zhiyin; Liu, Dan; Dai, Yimin; Li, Ruotian; Zheng, Yaowu; Zhao, Guangfeng; Wang, Jingmei; Diao, Zhenyu; Cao, Chenrui; Lv, Haining; Gu, Ning; Zhou, Hang; Ding, Hailin; Li, Jie; Zhu, Xiangyu; Duan, Honglei; Shen, Li; Zhang, Qun; Chen, Jing; Hu, Huilian; Wang, Xiaoyan; Zheng, Mingming; Zhou, Yan; Hu, Yali
• Is Part Of: Hypertension. Volume 80:Issue 2(2022)
• Page Start: 370
• Page End: 384
• Publication Date: 2022-12-15
• Subjects: miR-155 -- placenta -- preeclampsia -- subtype -- transgenic mice; Hypertension -- Periodicals; Hypertension -- Treatment -- Periodicals; 616.132005
• DOI: 10.1161/HYPERTENSIONAHA.122.19914
• Languages: English
• ISSNs: 0194-911X

Abstract

Abstract : Background: Preeclampsia is a complicated syndrome with marked heterogeneity. The biomarker-based classification for this syndrome is more constructive to the targeted prevention and treatment of preeclampsia. It has been reported that preeclamptic patients had elevated microRNA-155 (miR-155) in placentas or circulation. Here, we investigated the characteristics of patients with high placental miR-155 (pl-miR-155). Methods: Based on the 95th percentile (P95) of pl-miR-155 in controls, preeclamptic patients were divided into high miR-155 group (≥P95) and normal miR-155 group (<P95). The changes of placental pathology, clinical manifestations, and placental transcriptome of preeclamptic patients were clustered by t-distributed stochastic neighbor embedding and hierarchical clustering analysis. The placental restricted miR-155 overexpression mouse model was constructed, and the phenotype, placental pathology, and transcriptome were evaluated. Furthermore, the therapeutic potential of antagonist of miR-155 was explored by administrating with antagomir-155. Results: About one-third of preeclamptic patients had high pl-miR-155 expression, which was positively correlated with circulating miR-155 levels. These patients could be clustered as 1 group, according to clinical manifestation, placental pathology, or transcriptomes by t-distributed stochastic neighbor embedding and hierarchical clustering analysis. Further, the pregnant mice with placental restricted miR-155 overexpression could simulate the changes of clinical signs, pathology, and transcriptome of placentas in patients with high pl-miR-155. AntagomiR-155 treatment relieved the preeclampsia-like phenotype and improved the placental vascular development in mice. Conclusions: There is at least 1 type of preeclampsia with upregulated miR-155 presenting more severe clinical manifestations. MiR-155 may be a potential therapeutic target in patients with high pl-miR-155.