Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease. Issue 11 (14th July 2022)

• Record Type: Journal Article
• Authors: Calabretto, Marianna; Di Carlo, Daniele; Falasca, Francesca; Mazzuti, Laura; Meacci, Arianna; Donato, Giuseppe; Greco, Nicoletta; Mezzatesta, Laura; Morrone, Anna; Turriziani, Ombretta; Picarelli, Antonio
• Is Part Of: European journal of gastroenterology & hepatology. Volume 34:Issue 11(2022)
• Page Start: 1107
• Page End: 1110
• Publication Date: 2022-07-14
• Subjects: adenovirus -- celiac disease -- cytomegalovirus -- Epstein–Barr virus -- gastrointestinal biopsies -- human herpesvirus 6; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Digestive organs -- Diseases; Liver -- Diseases; Periodicals; 616.33
• DOI: 10.1097/MEG.0000000000002404
• Languages: English
• ISSNs: 0954-691X

Abstract

Abstract : Objective: The purpose of this study was to investigate the presence of Adenovirus, Epstein–Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients. Methods: Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms. Results: HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group. Conclusion: These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease.