Spatial distribution of Escherichia coli ST131 C subclades in a centralized Canadian urban region. (6th February 2021)

• Record Type: Journal Article
• Authors: Nobrega, Diego; Peirano, Gisele; Lynch, Tarah; Finn, Thomas J; Devinney, Rebekah; Pitout, Johann D D
• Is Part Of: Journal of antimicrobial chemotherapy. Volume 76:Number 5(2021)
• Page Start: 1135
• Page End: 1139
• Publication Date: 2021-02-06
• Subjects: Anti-infective agents -- Periodicals; Chemotherapy -- Periodicals; 615.58
• DOI: 10.1093/jac/dkab020
• Languages: English
• ISSNs: 0305-7453

Abstract

Abstract: Introduction: Escherichia coli ST131 is the most common multidrug-resistant (MDR) E. coli clone causing bloodstream infections (BSIs) in Calgary. This study describes patient characteristics and spatial distribution of ST131 subclades C1 and C2 causing BSIs in Calgary. Methods: E. coli from blood ( n = 685) obtained in Calgary, Canada, (2016) were PCR screened for ST131 and positives ( n = 141) underwent whole genome sequencing. Patient characteristics were analysed using Fisher's Exact/ t -tests and spatial analysis was used to identify clusters. Results: Overall, 21% of E. coli was identified as ST131 and clade C dominated the population. ST131-C2 was associated with bla CTX-M-15 and significantly more MDR than ST131-C1. The spatial distribution in Calgary showed that ST131-C1 was mainly present in long-term care (LTC) residents whereas ST131-C2 clustered in a specific North East (NE) Calgary sector comprising of six neighbourhoods without LTC centres. This NE sector has high immigration and travel rates from the Indian subcontinent. Conclusions: This study showed that ST131 C subclades have different geographical distribution patterns in Calgary. We believe that recent travel to and immigration from certain high-risk regions for antimicrobial resistance are responsible for the ST131-C2 NE Calgary clustering pattern.