MicroRNAs in ischaemic cardiovascular diseases. (29th April 2016)

• Record Type: Journal Article
• Authors: Greco, Simona; Zaccagnini, Germana; Voellenkle, Christine; Martelli, Fabio
• Is Part Of: European heart journal supplements. Volume 18(2016)Supplement E
• Page Start: E31
• Page End: E36
• Publication Date: 2016-04-29
• Subjects: microRNA -- Cardiovascular diseases -- Ischaemia -- Hypoxia; Cardiology -- Periodicals; Cardiology -- Europe -- Periodicals; 616.12005
• DOI: 10.1093/eurheartj/suw012
• Languages: English
• ISSNs: 1520-765X

Abstract

Abstract: microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is disrupted in many cardiovascular diseases. This review describes studies performed at Policlinico San Donato-IRCCS in cell cultures, animal models, and patients, showing a penetrant role of miRNAs in cell response to hypoxia and in ischaemic cardiovascular diseases. These experiments indicate miRNA as an emerging class of therapeutic targets.