C1-symmetric aza-crown ethers as chiral shift agents for amines and amino acid derivatives. (26th January 2023) - Feng, Qi-Yun
Abstract: Reported herein is our recent research progress in the development of macrocyclic chiral recognition studies. Highly enantiopure C 1 -symmetric aza-crown ethers, which were prepared previously by our lab from catalytic enantioselective symmetry-breaking C (sp 3 )-H bond transformation of readily available and inexpensive aza-crown ethers, were useful 1 H NMR chiral shift reagents to resolve racemic amines and amino acid derivatives, providing an easy and rapid NMR assay of enantiomeric purity of chiral compounds, especially chromophore-devoid ones that are not detected and quantified by colorimetric method. Graphical abstract: To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Image 1