Diagnosis by metagenomic next-generation sequencing of invasive pulmonary aspergillosis in an infant with chronic granulomatous disease. (2023)

• Record Type: Journal Article
• Authors: Yang, Aimei; Wang, Chun; Chen, Peiling; Zheng, Guilang; Zhao, Zhenjun; Liu, Jian; Zhang, Jingwen; Wang, Jing; Sun, Yueyu; Yang, Juhua; Guo, Yuxiong
• Is Part Of: Respiratory medicine case reports. Volume 41(2023)
• Publication Date: 2023
• Subjects: Aspergillus fumigatus -- Chronic granulomatous disease -- Bronchoalveolar lavage fluid -- Metagenomic next-generation sequencing -- Case report; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2022.101792
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Invasive pulmonary aspergillosis (IPA) is a serious fungal infection, with a high degree of mortality in immunocompromised individuals. Diagnosis of IPA is challenging in that clinical manifestations are not specific, with sensitivity of traditional detection procedures low. We report a case of IPA in a chronic granulomatous disease (CGD) infant who was initially suspected to have a lung tumor. Aspergillus fumigatus was identified as the pathogen in bronchoalveolar lavage fluid (BALF) by next-generation sequencing (mNGS). The patient recovered rapidly following a change of appropriate antifungal treatment and was discharged. This case highlights the additional value of BALF-mNGS for the diagnosis of pediatric invasive pulmonary fungal infection in immune-deficient children.