Functional regulation of decidual macrophages during pregnancy. (February 2021)

• Record Type: Journal Article
• Authors: Sun, Fengrun; Wang, Songcun; Du, Meirong
• Is Part Of: Journal of reproductive immunology. Volume 143(2021)
• Publication Date: 2021-02
• Subjects: DIC decidual immune cells -- DSC decidual stromal cells -- LPS lipopolysaccharide GM-CSF: granulocyte-macrophage colony-stimulating factor -- M-CSF macrophage colony-stimulating factor -- BM bone marrow -- MPS mononuclear phagocyte system -- DC dendritic cell -- MDP monocyte-macrophage DC progenitor -- HSC hematopoietic stem cell -- CMP common myeloid progenitor -- GMP granulocyte/macrophage progenitor -- CDP common DC progenitor -- cMOP common monocyte progenitor -- YS yolk sac -- AGM aorta-gonad-mesonephro -- CSF-1 growth factor colony-stimulating factor 1 -- EVT extravillous trophoblast cell -- ECM extracellular matrix -- RANKL receptor activator for nuclear factor-κB ligand -- VSMC vascular smooth muscle cell -- VEGF vascular endothelial growth factor -- PRL prolactin -- IGFBP-1 insulin growth factor binding protein-1 -- ICAM-1 intercellular adhesion molecule-1 -- PKA protein kinase A -- SP-A surfactant protein-A -- SP-D surfactant protein-D;Tim-3: T-cell immunoglobulin and mucin-domain containing-3 -- PGE2 prostaglandin E2 -- CTLA-4 cytotoxic T-lymphocyte antigen 4, miR: microRNA -- APC antigen presenting cell；dDC: decidual dendritic cell; Decidual macrophages -- Pregnancy complications -- Trophoblast invasion -- Spiral arterial remodeling -- Maternal-fetal tolerance; Reproduction -- Immunological aspects -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Reproduction -- Periodicals; Reproduction -- Immunologie -- Périodiques; Immunologie -- Périodiques; Immunology; Reproduction -- Immunological aspects; Periodicals; Electronic journals; Electronic journals; 615.766
• DOI: 10.1016/j.jri.2020.103264
• Languages: English
• ISSNs: 0165-0378

Abstract

Highlights: Decidual macrophages may originate from both embryonic macrophages and hematopoietic stem cells-derived macrophages in bone marrow. Decidual macrophages possess unique phenotypes different from peripheral macrophages, which alter in different phases of pregnancy. Decidual macrophages play irreplaceable roles in key events of normal pregnancy. Decidual macrophages dysfunction is closely related to pregnancy implications. Abstract: A successful pregnancy requires that the maternal immune system recognizes and tolerates the semi-allogeneic fetus without compromising the capability of protecting both mother and fetus from various pathogens. Decidual macrophages present unique phenotypes to play a key role in the establishment of the immunological aspects of maternal-fetal interaction. Dysfunction of decidual macrophages gives rise to pregnancy complications such as preeclampsia, recurrent spontaneous miscarriage, preterm labor and fetal growth restriction. Here, we reviewed the latest knowledge on the origin, differentiation, unique phenotype and function of macrophages in normal pregnancy and in pregnancy complications. We mainly focused on the significant roles of decidual macrophages in the process of extravillous trophoblast invasion, spiral arterial remodeling, decidual stromal cells cultivation and immune tolerance maintenance in normal pregnancy, and their pathological roles in pregnancy-related complications, offering more integrated information in maternal-fetal immunity.