P768Increased carotid artery stiffness in coronary artery disease assessed by speckle-tracking and its good association with aortic stiffness and endothelial dysfunction. (15th July 2014)

• Record Type: Journal Article
• Authors: El Ghannudi, S; Ngheim, A; Germain, P; Jeung, MI-Y; Geny, B; Gangi, A; Roy, C
• Is Part Of: Cardiovascular research. Volume 103(2014)Supplement 1
• Page Start: S141
• Page End: S141
• Publication Date: 2014-07-15
• Subjects: Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Periodicals; 616.1
• DOI: 10.1093/cvr/cvu098.186
• Languages: English
• ISSNs: 0008-6363

Abstract

Abstract: Aim: (i) evaluate carotid artery strain derived from speckle tracking ultrasound imaging (CAS) in subjects with coronary artery disease (CAD) and without coronary artery disease (N-CAD), (ii) compare CAS, to global aortic stiffness using carotid-femoral pulse wave velocity (c-f PWV) and to endothelial function using brachial flow-mediated dilatation (FMD) in subjects with CAD. Methods: 100 subjects were prospectively included, and classified into 2 groups: subjects with CAD (CAD, n=49), subjects N-CAD (N-CAD, n=51). The CAS on the common carotid artery using speckle-tracking ultrasound imaging (Vivid 7, General Electric) was measured. In the CAD, c-f PWV and FMD were evaluated and compared to CS. Results: Age of the population was 65±1.7 years. The proportion of males, diabetes and obesity in CAD was higher than N-CMD group (p=0.0005, p=0.0002, 0.0004 respectively). There was no significant difference in age and hypertension. In a multivariate analysis, age and CAD were the sole independent predictors of CAS (r=−0.6, p<0.0001; r=-0.5, p<0.0001 respectively). The CAS was significantly lower in CAD as compared to N-CAD (2.41% vs 4.48%, p<0.0001). In CAD group, 41% presented stable angina and 59 % acute coronary syndrome (ACS). The CAS was lower in stable angina vs ACS (1.85% vs 2.92%, p=0.02). In the CAD group, CAS was inversely correlated to c-f PWV (r=−0.7, p=0.0001), and correlated with endothelial dysfunction (r=0.45, p=0.003). Conclusion: Speckle-tracking ultrasound imaging is a non-invasive technique useful for the evaluation of local carotid artery stiffness. Carotid artery stiffness was higher in coronary artery disease. In CAD, carotid artery stiffness measured by speckle-tracking is associated with global aortic stiffness and endothelial dysfunction.