Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases. Issue 11 (7th August 2020)

• Record Type: Journal Article
• Authors: Freites Nuñez, Dalifer D; Leon, Leticia; Mucientes, Arkaitz; Rodriguez-Rodriguez, Luis; Font Urgelles, Judit; Madrid García, Alfredo; Colomer, Jose I; Jover, Juan A; Fernandez-Gutierrez, Benjamín; Abasolo, Lydia
• Is Part Of: Annals of the rheumatic diseases. Volume 79:Issue 11(2020)
• Page Start: 1393
• Page End: 1399
• Publication Date: 2020-08-07
• Subjects: antirheumatic agents -- communicable diseases -- imported -- epidemiology -- outcome assessment -- health care; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2020-217984
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. Methods: An observational longitudinal study was conducted during the pandemic peak of severe acute respiratory syndrome coronavirus 2 (1 March 2020 to 24 April). All patients attended at the rheumatology outpatient clinic of a tertiary hospital in Madrid, Spain with a medical diagnosis of AIRD and with symptomatic COVID-19 were included. The main outcome was hospital admission related to COVID-19. The covariates were sociodemographic, clinical and treatments. We ran a multivariable logistic regression model to assess risk factors for the hospital admission. Results: The study population included 123 patients with AIRD and COVID-19. Of these, 54 patients required hospital admission related to COVID-19. The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3–10) days. The median length of stay was 9 (6–14) days. A total of 12 patients died (22%) during admission. Compared with outpatients, the factors independently associated with hospital admission were older age (OR: 1.08; p=0.00) and autoimmune systemic condition (vs chronic inflammatory arthritis) (OR: 3.55; p=0.01). No statistically significant findings for exposure to disease-modifying antirheumatic drugs were found in the final model. Conclusion: Our results suggest that age and having a systemic autoimmune condition increased the risk of hospital admission, whereas disease-modifying antirheumatic drugs were not associated with hospital admission.