Cognitive decline and dementia in women after menopause: Prevention strategies. (February 2023)

• Record Type: Journal Article
• Authors: Stefanowski, Bogdan; Kucharski, Marek; Szeliga, Anna; Snopek, Milena; Kostrzak, Anna; Smolarczyk, Roman; Maciejewska-Jeske, Marzena; Duszewska, Anna; Niwczyk, Olga; Drozd, Slawomir; Englert-Golon, Monika; Smolarczyk, Katarzyna; Meczekalski, Blazej
• Is Part Of: Maturitas. Volume 168(2023)
• Page Start: 53
• Page End: 61
• Publication Date: 2023-02
• Subjects: AD Alzheimer's disease -- ADL activities of daily living -- CD cognitive decline -- CEE conjugated equine estrogens -- CRF cardiovascular factors -- DHPROG dihydroprogesterone -- DLB dementia with Lewy bodies -- DR's EXTRA Dose Responses to Exercise Training -- E2 17-beta estradiol -- FINGER Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability -- FSH follicle-stimulating hormone -- HRT hormonal replacement therapy -- MAPT Multidomain Alzheimer Preventive Trial -- MCI mild cognitive impairment -- MCSA Mayo Clinic Study of Aging -- MHT menopausal hormone therapy -- MPA medroxyprogesterone acetate -- NTB neuropsychological test battery -- PD Parkinson's disease -- PReDIVA Prevention of Dementia by Intensive Vascular Care -- SBP standard blood pressure -- THPROG tetrahydroprogesterone -- WHIMS Women's Health Initiative Memor Study -- WW-FINGERS World-Wide FINGERS; Cognitive decline -- Menopause -- Hormone replacement therapy; Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2022.10.012
• Languages: English
• ISSNs: 0378-5122

Abstract

Highlights: Cognitive decline is one of the biggest challenges for public health. The menopausal transition is associated with cognitive changes which are mild and usually do not affect normal functioning. Menopausal symptoms can aggravate cognitive changes during the menopausal transition. Menopausal hormone therapy appears to have no deleterious effects on cognition. Addressing modifiable risk factors, such as cardiovascular risk factors, diabetes and lifestyle, can have a significant protective effect against cognitive decline and dementia. Abstract: Worldwide, cognitive decline and dementia are becoming one of the biggest challenges for public health. The decline in cognition and the development of dementia may be caused by predisposing or trigger factors. There is no consensus over whether the drop in estrogen levels after menopause is a risk factor for cognitive decline and dementia. This article discusses the prevention of cognitive decline and dementia in women after menopause, both primary prevention (essentially pharmacological intervention) and secondary prevention (chiefly diet and weight reduction). Further study is required to clarify whether menopausal hormone therapy (MHT) has a role in dementia.