3D conductive material strategies for modulating and monitoring cells. (March 2023)

• Record Type: Journal Article
• Authors: Li, Xiao; Mao, Mao; Han, Kang; Yao, Cong; Gu, Bingsong; He, Jiankang; Li, Dichen
• Is Part Of: Progress in materials science. Volume 133(2023)
• Publication Date: 2023-03
• Subjects: 3D bioengineered structures -- Conductive materials -- Fabrication techniques -- Tissue engineering -- Bioelectronics -- Biosensors; AuNP gold nanoparticle -- AuNW gold nanowire -- Ce electrode capacitance -- Cjm junctional membrane capacitance -- Cm membrane capacitance -- CIJ continuous inkjet -- CNF carbon nanofiber -- CNS central nervous system -- CNT carbon nanotube -- cTnI cardiac troponin I -- Cx43 connexin 43 -- DOD drop-on-demand -- DRG dorsal root ganglia -- EBL electron beam lithography -- EHDP electrohydrodynamic printing -- FA focal adhesion -- FET field-effect transistor -- FNC flexible neural clip -- GAP43 growth-associated protein 43 -- GelMA gelatin methacryloyl -- G-GNR gelatin-methacryloyl-coated gold nanorod -- GO graphene oxide -- iPSC induced pluripotent stem cell -- I/O input/output -- MEA microelectrode array -- MSC mesenchymal stem cell -- MWCNT multi-walled carbon nanotube -- N‐CNT nitrogen‐doped carbon nanotube -- NeuE neuron-like electronic -- NGC nerve guidance conduit -- OECT organic electrochemical transistor -- PAni polyaniline -- PCL polycaprolactone -- PDMS polydimethylsiloxane -- PEDOT poly(3, 4-ethylenedioxythiophene) -- PEG polyethylene glycol -- PEGDA polyethylene glycol diacrylate -- PG poly(glyceryl sebacate):gelatin -- PLGA poly(lactic-co-glycolic acid) -- PLLA poly-l-lactic acid -- PNS peripheral nervous system -- PPy polypyrrole -- PSS poly(styrenesulfonate) -- PtNP platinum nanoparticle -- PVDF poly(vinylidene fluoride) -- Ra access resistance -- Re electrode resistance -- rGO reduced graphene oxide -- Rm membrane resistance -- Rs seal resistance -- SEM scanning electron microscopy -- SF silk fibroin -- SiNW silicon nanowire -- SL stereolithography -- SNR signal-to-noise ratio -- SWCNT single-walled carbon nanotube -- TPP two-photon polymerization -- TrFE fluoridetriflouroethylene -- UV ultraviolet; Materials science -- Periodicals; Science des matériaux -- Périodiques; 620.1105
• DOI: 10.1016/j.pmatsci.2022.101041
• Languages: English
• ISSNs: 0079-6425

Abstract

Abstract: Electrically conductive materials have been integrated into 3D bioengineered structures, such as tissue-engineered scaffolds, in vitro biological models, and therapeutic devices, to interface with cells and tissues for improving cell growth, differentiation, and functions. In recent years, remarkable efforts have been devoted to transforming conductive materials in 3D bioengineered structures into electronic components for stimulating cells and recording cellular signals. This emerging research frontier holds great promise to generate effective tools for understanding and manipulating biological systems, and its development calls for expertise across a broad range of research fields. In this article, we survey the state-of-the-art advances regarding 3D conductive bioengineered structures for modulating and monitoring cells in four critical aspects: basic conductive materials with distinctive characteristics can serve as building blocks; the design of conductive bioengineered structures can draw on the growing mechanistic understanding of structure–cell interplays; fabrication techniques have rapidly advanced to generate 3D bioengineered structures with complex electronic components for stimulating and sensing functionalities; furthermore, the applications of novel 3D conductive bioengineered structures have made a considerable impact on various biomedical fields. Finally, we discuss the future outlook and challenges for deeper integration and closer interactions between 3D conductive bioengineered structures and biological systems.