Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease. (1st February 2023)

• Record Type: Journal Article
• Authors: Purohit, Manish; Gupta, Gaurav; Afzal, Obaid; Altamimi, Abdulmalik Saleh Alfawaz; Alzarea, Sami I.; Kazmi, Imran; Almalki, Waleed Hassan; Gulati, Monica; Kaur, Indu Pal; Singh, Sachin Kumar; Dua, Kamal
• Is Part Of: Chemico-biological interactions. Volume 371(2023)
• Publication Date: 2023-02-01
• Subjects: JAK -- STAT -- Inflammatory lung diseases -- COPD -- Asthma; Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2023.110334
• Languages: English
• ISSNs: 0009-2797

Abstract

Abstract: A key signaling channel for the signal transduction of several crucial cytokines implicated in sepsis is the JAK/STAT system. Once cytokines attach to the proper receptors, JAK kinases linked to them are activated and can selectively phosphorylate STATs. Activated STATs subsequently go to the nucleus, where they play a key role in the transcription of the target genes. Various biological activities use the JAK/STAT pathway, including hematopoiesis, immunological modulation, cell differentiation, and apoptosis. Inflammatory lung illnesses affect people worldwide and are a serious public health concern. Numerous common respiratory conditions, such as asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome, are strongly influenced by inflammation. Microorganism infections or the destruction or demise of host cells are the causes of inflammation and the factors that perpetuate it. This review discusses the main elements of severe lung inflammation and how the JAK/STAT signaling pathway is essential for lung inflammation. Highlights: JAK/STAT signaling pathway is connected to type 1 and 2 cytokine receptors. JAK/STAT sends extracellular information to the cell nucleus. This review examines severe lung inflammation and the JAK/STAT signalling pathway's role.