CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Issue 1 (28th January 2021)

• Record Type: Journal Article
• Authors: Fountain, Daniel M; Piper, Rory J; Poon, Michael T C; Solomou, Georgios; Brennan, Paul M; Chowdhury, Yasir A; Colombo, Francesca; Elmoslemany, Tarek; Ewbank, Frederick G; Grundy, Paul L; Hasan, Md T; Hilling, Molly; Hutchinson, Peter J; Karabatsou, Konstantina; Kolias, Angelos G; McSorley, Nathan J; Millward, Christopher P; Phang, Isaac; Plaha, Puneet; Price, Stephen J; Rominiyi, Ola; Sage, William; Shumon, Syed; Silva, Ines L; Smith, Stuart J; Surash, Surash; Thomson, Simon; Lau, Jun Y; Watts, Colin; Jenkinson, Michael D
• Is Part Of: Neuro-oncology advances. Volume 3:Issue 1(2021)
• Publication Date: 2021-01-28
• Subjects: brain tumor -- COVID-19 -- intracranial tumor -- neuro-oncology -- SARS-CoV-2; 616.99481
• DOI: 10.1093/noajnl/vdab014
• Languages: English
• ISSNs: 2632-2498

Abstract

Abstract: Background: The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors. Methods: We performed a multicenter prospective study of all adult patients discussed in weekly neuro-oncology and skull base multidisciplinary team meetings who had a newly diagnosed or recurrent intracranial (excluding pituitary) tumor between 01 April and 31 May 2020. All patients had at least 30-day follow-up data. Descriptive statistical reporting was used. Results: There were 1357 referrals for newly diagnosed or recurrent intracranial tumors across 15 neuro-oncology centers. Of centers with all intracranial tumors, a change in initial management was reported in 8.6% of cases ( n = 104/1210). Decisions to change the management plan reduced over time from a peak of 19% referrals at the start of the study to 0% by the end of the study period. Changes in management were reported in 16% ( n = 75/466) of cases previously recommended for surgery and 28% of cases previously recommended for chemotherapy ( n = 20/72). The reported SARS-CoV-2 infection rate was similar in surgical and non-surgical patients (2.6% vs. 2.4%, P > .9). Conclusions: Disruption to neuro-oncology services in the UK caused by the COVID-19 pandemic was most marked in the first month, affecting all diagnoses. Patients considered for chemotherapy were most affected. In those recommended surgical treatment this was successfully completed. Longer-term outcome data will evaluate oncological treatments received by these patients and overall survival.