Vulval disease in HIV-positive women attending a tertiary vulval dermatology clinic over a five-year period. (October 2013)

• Record Type: Journal Article
• Authors: Dosekun, Olamide; Farrugia, Pippa; Lewis, Fiona; Sethi, Gulshan
• Is Part Of: International journal of STD & AIDS. Volume 24:Number 10(2013)
• Page Start: 834
• Page End: 836
• Publication Date: 2013-10
• Subjects: Women -- human papillomavirus -- herpes simplex virus -- human immunodeficiency virus -- HIV -- AIDS -- dermatosis -- VIN; Sexually transmitted diseases -- Periodicals; AIDS (Disease) -- Periodicals; 616.951
• DOI: 10.1177/0956462413486458
• Languages: English
• ISSNs: 0956-4624

Abstract

There is a paucity of data on vulval disease in HIV-infected women. We describe the spectrum of vulval disease in HIV-infected women attending a tertiary vulval dermatology referral centre over a five-year period. Seven vulval conditions were identified in 14 women. Most were attending for HIV care ( n = 12, 86%), and on combined antiretroviral therapy (CART) with a CD4 cell count above 200 cells/µL ( n = 9, 64%) at diagnosis. Imiquimod therapy was effective in treating undifferentiated vulval intraepithelial neoplasia (uVIN) – the most common diagnosis. There were no cases of invasive vulval carcinoma. Hypertrophic herpes simplex virus occurred in one woman stable on CART with good immune reconstitution. Clinicians should be vigilant about the spectrum of vulval disease in HIV-infected women and consider genital examination as part of routine care.