942. Comparison of Antibiotic Susceptibility Across Minnesota Hospitals in 2019 and 2020 Using a New Statewide Antibiogram. (15th December 2022)

• Record Type: Journal Article
• Authors: Anderson, Jadyn C; Hirsch, Elizabeth B; Rivers, Jennifer; Beaudoin, Amanda; Spaulding, Alicen B
• Is Part Of: Open forum infectious diseases. Volume 9:(2022)Supplement 2
• Publication Date: 2022-12-15
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac492.785
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Surveillance is imperative to successful antibiotic stewardship, but active surveillance is resource-intensive. Regional antibiograms provide a supplementary method of surveillance while conserving resources. We developed the first statewide antibiograms to track susceptibility across the state of Minnesota and compared 2019 and 2020 data. Methods: Hospital antibiograms for 2019 and 2020 were submitted to the Minnesota Department of Health in January 2022. Twelve organisms ( Enterococcus faecalis, Enterococcus faecium, methicillin-resistant Staphylococcus aureus, methicillin-susceptible S. aureus, S. aureus, Acinetobacter spp., Enterobacter spp., Escherichia coli, Klebsiella aerogenes, K. oxytoca, K. pneumoniae, and Pseudomonas aeruginosa ) were selected for analysis against 32 drugs, leading to a total of 142 unique organism/agent combinations. The number of isolates and percent susceptibility from each antibiogram were used to calculate a weighted average percent susceptibility as the state-level susceptibility. Chi-square analysis compared the proportion of susceptible to non-susceptible isolates between the years. Results: Submitted antibiograms (n=40) represented 30% of Minnesota hospitals. The total number of isolates reported decreased by 5% from 2019 (n=85, 010) to 2020 (n=80, 781), with E. coli having the greatest proportion (2019=41.7%, 2020=39.5%) of the total isolates. Significant changes in susceptibility proportions occurred in 33% of analyzed organism/agent combinations, with 68% of these showing increased susceptibility in 2020 compared to 2019. All antibiotics tested against P. aeruginosa demonstrated a statistical increase in susceptibility from 2019 to 2020 (Figure 1). Figure 1 Statewide susceptibility profile of P. aeruginosa in Minnesota, 2019 and 2020. Antimicrobial agents grouped by class from narrow spectrum to broad spectrum, cephalosporins ordered by generation. *denotes statistical significance (p<0.05). Conclusion: Analysis of statewide antibiograms for 2019 and 2020 demonstrated overall stability in antimicrobial susceptibility, with two-thirds of organism/agent combinations showing no significant changes. In those with significant changes, the majority exhibited an increase in susceptibility. Susceptibility changed more frequently in gram-negative organisms than gram-positive organisms. Ongoing collection of antibiograms will be used to assess regional and statewide susceptibility trends across Minnesota. Disclosures: Elizabeth B. Hirsch, PharmD, FCCP, FIDSA, Melinta: Advisor/Consultant|MeMed: Advisor/Consultant|Merck: Advisor/Consultant|Merck: Grant/Research Support.