Association of dual COVID-19 and seasonal influenza vaccination with COVID-19 infection and disease severity. Issue 4 (23rd January 2023)

• Record Type: Journal Article
• Authors: Xie, Zhigang; Hamadi, Hanadi Y.; Mainous, Arch G.; Hong, Young-Rock
• Is Part Of: Vaccine. Volume 41:Issue 4(2023)
• Page Start: 875
• Page End: 878
• Publication Date: 2023-01-23
• Subjects: COVID-19 -- Influenza -- Dual vaccination; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2022.12.043
• Languages: English
• ISSNs: 0264-410X

Abstract

Highlights: Dual vaccinations are associated with reduced COVID-19 infection than unvaccinated individuals. Dual and COVID-19-only vaccinations seem to have comparable associations with COVID-19 infection. Dual vaccination may be an effective strategy to reduce the contagious respiratory disease burden. Abstract: The clinical guideline states that COVID-19 vaccination can be administered concurrently with Influenza (flu) vaccination (dual vaccination). Using data from the 2021 National Health Interview Survey, we conducted descriptive analysis and multivariate logistic regressions to examine the association between dual vaccination status and self-reported COVID-19 infection and severity. Among 21, 387 (weighted 185, 251, 310) U.S. adults, about 22% did not receive either the flu or COVID-19 vaccine, 6.0% received the flu vaccine only, 29.1% received the COVID-19 vaccine only, and 42.5% received both vaccines. In the multivariate analysis, individuals with dual vaccination (OR, 0.65, 95% CI, 0.56–0.75) and COVID-19 vaccine only (OR, 0.71, 95% CI, 0.61–0.82) were significantly less likely to report COVID-19 infection when compared with those unvaccinated. There was no significant difference in self-reported COVID-19 symptom severity by vaccination status. The results suggest that dual vaccination may be an effective strategy to reduce the contagious respiratory disease burden.