Parahydrogen‐Induced Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation. (19th December 2022)

• Record Type: Journal Article
• Authors: Nelson, Christopher; Schmidt, Andreas B.; Adelabu, Isaiah; Nantogma, Shiraz; Kiselev, Valerij G.; Abdurraheem, Abubakar; de Maissin, Henri; Lehmkuhl, Sören; Appelt, Stephan; Theis, Thomas; Chekmenev, Eduard Y.
• Is Part Of: Angewandte Chemie. Volume 135:Number 5(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-19
• Subjects: Carbon-13 -- Hyperpolarization -- NMR Spectroscopy -- Parahydrogen -- RASER; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202215678
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The feasibility of Carbon‐13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C‐13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1‐ 13 C]acetate. Hyperpolarized ethyl [1‐ 13 C]acetate was prepared via pairwise addition of parahydrogen to vinyl [1‐ 13 C]acetate and polarization transfer from nascent parahydrogen‐derived protons to the carbon‐13 nucleus via magnetic field cycling yielding C‐13 nuclear spin polarization of approximately 6 %. RASER signals were detected from samples with concentration ranging from 0.12 to 1 M concentration using a non‐cryogenic 1.4T NMR spectrometer equipped with a radio‐frequency detection coil with a quality factor ( Q ) of 32 without any modifications. C‐13 RASER signals were observed for several minutes on a single bolus of hyperpolarized substrate to achieve 21 mHz NMR linewidths. The feasibility of creating long‐lasting C‐13 RASER on biomolecular carriers opens a wide range of new opportunities for the rapidly expanding field of C‐13 magnetic resonance hyperpolarization. Abstract : Carbon‐13 Radiofrequency Amplification by Stimulated Emission of Radiation (C‐13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1‐ 13 C]acetate. Spontaneous RASER signal emissions were detected using a non‐cryogenic 1.4T NMR spectrometer equipped with a radio‐frequency detection coil with a quality factor of 32 without any modifications for over 3 minutes, paving the way to new frontiers for HP 13 C contrast agents.