Treatment of Aspirin Exacerbated Respiratory Disease with a Low Salicylate Diet: A Pilot Crossover Study. (24th October 2014)

• Record Type: Journal Article
• Authors: Sommer, Doron D.; Hoffbauer, Stephanie; Au, Michael; Sowerby, Leigh J.; Gupta, Michael K.; Nayan, Smriti
• Is Part Of: Otolaryngology--head and neck surgery. Volume 152:Number 1(2015:Jan.)
• Page Start: 42
• Page End: 47
• Publication Date: 2014-10-24
• Subjects: nasal polyps -- sinusitis -- asthma -- salicylates -- aspirin exacerbated respiratory disease -- low salicylate diet; Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0194599814555836
• Languages: English
• ISSNs: 0194-5998

Abstract

Abstract : Objective: Aspirin exacerbated respiratory disease (AERD) is comprised of aspirin/acetylsalicylic acid (ASA) sensitivity, bronchial asthma, and nasal polyposis. Treatment of this condition is challenging and may include topical/systemic steroids, endoscopic sinus surgery, and/or aspirin desensitization. Study Design: A prospective crossover pilot study (n = 10) was conducted in which patients were randomized into either of 2 groups with 6 weeks of regular diet (R) or 6 weeks of a low salicylate diet (LS). Setting: The study was conducted in a tertiary otolaryngology clinic. Subjects: Patients with AERD were enrolled in the study. Methods: Subjective (Sino‐nasal Outcome Test‐22 [SNOT‐22], Nasal Sinus Symptom Scale [NSSS], and the Asthma Control Questionnaire‐7 [ACQ‐7]) and objective outcome instruments (Peri‐Operative Sinus Evaluation [POSE] and Lund‐Kennedy Endoscopic Score [LKES]) were used to evaluate patients at baseline, 6 weeks (at crossover), and 12 weeks. Results: Wilcoxon rank sum tests demonstrated that patients on the low salicylate diet had improved scores compared to their regular diet when evaluated by 4 of the 5 outcome measures (SNOT‐22 pLS = 0.0059, NSSS pLS = 0.0195, LKES pLS = 0.0039, POSE pLS = 0.005). Conclusion: Results of the pilot study indicate that implementation of a low salicylate diet improves the nasal symptoms and nasal endoscopy findings of individuals with AERD. Further research is required to support these findings.