Electric field aspects in hypoglossal nerve stimulation for obstructive sleep apnea: A bilateral electrophysiological evaluation of unilateral electrode configuration changes. (21st May 2022)

• Record Type: Journal Article
• Authors: Steffen, Armin; Moritz, Florian Joffrey; König, Inke R.; Suurna, Maria V.; Brüggemann, Norbert
• Is Part Of: Journal of sleep research. Volume 32:Number 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-21
• Subjects: electric field -- electrode configuration -- electromyography -- hypoglossal nerve stimulation -- polysomnography -- sleep apnea; Sleep -- Periodicals; Sleep disorders -- Periodicals; 612.821
• DOI: 10.1111/jsr.13592
• Languages: English
• ISSNs: 0962-1105

Abstract

Summary: Hypoglossal nerve stimulation is an established treatment option for obstructive sleep apnea in selected patients. A unilateral hypoglossal nerve stimulation system was approved a decade ago, yet the physiological effect of unilateral hypoglossal stimulation on bilateral tongue motion remains unclear. This study examined how electrode configuration, stimulation cuff position, or body mass index influenced the contralateral genioglossus electromyography (EMG) signal. Twenty‐nine patients underwent three EMG recordings in a polysomnographic setting after being implanted with a unilateral hypoglossal nerve stimulator for at least 6 months. The ratio of EMG signals between the ipsi‐ and contralateral sides was evaluated. No difference in EMG signals was demonstrated based on electrode configurations, stimulation‐cuff position, body‐mass‐index, or sleep apnea severity, even in patients with right tongue protrusion only. Our findings may be explained by a significant level of cross‐innervation and by a smaller and less variable circumferential electric field than expected based on prior biophysical models. A patient's individual anatomy needs to be considered during therapy titration in order to achieve an optimal response.