A yeast for all seasons – Is Pichia pastoris a suitable chassis organism for future bioproduction?. Issue 17 (19th July 2018)

• Record Type: Journal Article
• Authors: Gasser, Brigitte; Mattanovich, Diethard
• Is Part Of: FEMS microbiology letters. Volume 365:Issue 17(2018:Sep.)
• Publication Date: 2018-07-19
• Subjects: Pichia pastoris -- Komagataella -- synthetic biology -- recombinant protein -- metabolic engineering -- bioeconomy; Microbiology -- Periodicals; 579
• DOI: 10.1093/femsle/fny181
• Languages: English
• ISSNs: 0378-1097

Abstract

Abstract: The methylotrophic yeast Pichia pastoris ( Komagataella spp .) is well established as a host for recombinant protein production. Since a few years it has also been subject to metabolic engineering to produce a diversity of biochemicals. Based on these developments we discuss here why P. pastoris is a suitable future chassis organism for synthetic biology, and we provide a roadmap for a community effort towards this aim. Abstract : This opinion paper discusses whether the yeast Pichia pastoris is a suitable chassis for synthetic biology applications, and provides guidelines how to achieve this.