Association Between Helicobacter pylori Infection and Otitis Media With Effusion Risk in Children: A Systematic Review and Meta‐analysis. (2nd June 2020)

• Record Type: Journal Article
• Authors: Wu, Xiaohui; Zheng, Yun; Gao, Xingqiang; Li, Gang; Cao, Qiuxue
• Is Part Of: Otolaryngology--head and neck surgery. Volume 163:Number 4(2020)
• Page Start: 654
• Page End: 661
• Publication Date: 2020-06-02
• Subjects: Helicobacter pylori -- infection -- otitis media with effusion -- children -- meta‐analysis; Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0194599820921861
• Languages: English
• ISSNs: 0194-5998

Abstract

Abstract : Objective: To investigate the potential correlation between Helicobacter pylori infection and otitis media with effusion (OME) risk in children. Data Sources: Electronic databases were searched, including Cochrane Library, PubMed, Embase, China Biology Medicine disc, China Science and Technology Journal Database, Wanfang Database, and China National Knowledge Infrastructure Database. Review Methods: A systematic review and meta‐analysis were conducted with Revman 5.3 software. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate infection‐disease association. Results: In total, 11 studies from 9 articles regarding H pylori infection and OME risk were enrolled in this meta‐analysis. A significant association between H pylori infection and OME was detected for both adenoid samples from the case group (OR, 2.75; 95% CI, 1.43‐5.30; P =. 002) and middle ear fluid samples from the case group (OR, 4.45; 95% CI, 2.52‐7.88; P <. 00001). Subgroup analyses suggested a stronger correlation in African and Asian populations. Conclusion: This study indicated the correlation between H pylori infection and increased risk of OME in children, especially in African and Asian populations. Further well‐designed studies regarding the white population are strongly recommended in the future.