Transition‐metal‐free Synthesis of tetra‐substituted Vinyl Iodides by Cascade Sequential Reaction of α‐Keto Acids, 1‐Iodoalkynes, and Alkyl Halides. Issue 2 (13th December 2022)

• Record Type: Journal Article
• Authors: Zeng, Xiaobao; Cheng, Zhenfeng; Xie, Yushan; Gu, Yunhui
• Is Part Of: Chemistry, an Asian journal. Volume 18:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-13
• Subjects: transition-metal-free -- cascade sequential reaction -- terta-substituted vinyl iodides -- 1-iodoalkynes -- α-keto acids; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.202201117
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: The cascade sequential reaction of α‐keto acids, 1‐iodoalkynes, and alkyl halides are reported herein to synthesize tetra ‐substituted vinyl iodides. It represents an efficient protocol to access a diverse range of tetra ‐substituted vinyl iodides starting from simple materials in a one‐pot fashion, featuring mild reaction conditions, ease of operation, and broad substrate scope. Abstract : A transition‐metal‐free approach to access diverse tetra ‐substituted vinyl iodides by a cascade sequential reaction of α‐keto acids, 1‐iodoalkynes, and alkyl halides is established herein.