Synthesis of Complex Dihydroisoquinolin Derivatives via Cobalt‐Electrocatalyzed C−H Activation. Issue 1 (4th January 2023)

• Record Type: Journal Article
• Authors: Huang, Yin‐Hui; Dong, Lin
• Is Part Of: Advanced synthesis & catalysis. Volume 365:Issue 1(2023)
• Page Start: 23
• Page End: 30
• Publication Date: 2023-01-04
• Subjects: C−H bond activation -- cobalt catalyst -- electrochemistry -- [4+2] annulation -- dihydroisoquinolin; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202201155
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We developed a cost‐effective cobalt‐catalyzed electrochemical annulation to generate diversified novel complex dihydroisoquinolin derivatives from amides and alkenes in a simple and maneuverable undivided cell. The reaction proceeded C−H/N−H activation, and the catalyst was regenerated by anodic oxidation. Notably, the strategy of electrocatalysis avoided the consumption of stoichiometric chemical oxidants. Abstract :