Enhanced Targeting, Retention, and Penetration of Amphotericin B Through a Biomimetic Strategy to Treat Against Vulvovaginal Candidiasis (Adv. Therap. 1/2023). Issue 1 (18th January 2023)

• Record Type: Journal Article
• Authors: Lin, Yijing; Yin, Qingqing; Zhuge, Deli; Hu, Yiqin; Yang, Xuewei; Tian, Dongyan; Li, Li; Wang, Haonan; Liu, Shuangshuang; Weng, Cuiye; Zhang, Xufei; Wen, Bin; Wang, Fang; Yan, Linzhi; Chen, Mengchun; Wang, Ledan; Chen, Yijie
• Is Part Of: Advanced therapeutics. Volume 6:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-18
• Subjects: Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.202370001
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract : Amphotericin B (AmB) preloaded polymeric cores cloaked with vaginal epithelial cells membrane (VM‐ANP) are capable of localizing to the sites of Candida albicans infection. Upon such strong adhesion, retention, and penetration, VM‐ANP shows a controlled release of AmB; thus, enhancing the fungal killing to reach its full potential. This is reported by Mengchun Chen, Ledan Wang, Yijie Chen, and co‐workers in article number 2200086 .