Clinical Reasoning: A 39-Year-Old Man With Asymmetric Distal Weakness and Loss of Sensitivity. (10th January 2023)

• Record Type: Journal Article
• Authors: Loser, Valentin; Blanchard, Gabriela; Guenova, Emmanuella; Théaudin, Marie; Vicino, Alex
• Is Part Of: Neurology. Volume 100:Number 2(2023)
• Page Start: 88
• Page End: 93
• Publication Date: 2023-01-10
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000201410
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : A 39-year-old man presented with an asymmetric distal weakness and loss of sensitivity sequentially affecting both lower extremities and the left upper limb. Nerve conduction studies showed a multifocal sensory and motor axonal neuropathy, and a pseudo-conduction block of the right fibular nerve, the whole being consistent with a mononeuropathy multiplex. An uncommon etiology was found after an extensive workup. Axonal loss was severe, with only partial response to treatment with corticosteroids and IV immunoglobulins.