The T Cell Journey: A Tour de Force. Issue 1 (3rd October 2022)

• Record Type: Journal Article
• Authors: Alatoom, Aseel; ElGindi, Mei; Sapudom, Jiranuwat; Teo, Jeremy C. M.
• Is Part Of: Advanced biology. Volume 7:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-10-03
• Subjects: adaptive immunity -- biomechanics -- immunomechanobiology -- mechanobiology -- T cells; Molecular biology -- Periodicals; Systems biology -- Periodicals; Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; 660.6
• DOI: 10.1002/adbi.202200173
• Languages: English
• ISSNs: 2701-0198

Abstract

Abstract: T cells act as the puppeteers in the adaptive immune response, and their dysfunction leads to the initiation and progression of pathological conditions. During their lifetime, T cells experience myriad forces that modulate their effector functions. These forces are imposed by interacting cells, surrounding tissues, and shear forces from fluid movement. In this review, a journey with T cells is made, from their development to their unique characteristics, including the early studies that uncovered their mechanosensitivity. Then the studies pertaining to the responses of T cell activation to changes in antigen‐presenting cells' physical properties, to their immediate surrounding extracellular matrix microenvironment, and flow conditions are highlighted. In addition, it is explored how pathological conditions like the tumor microenvironment can hinder T cells and allow cancer cells to escape elimination. Abstract : T cells experience a myriad of forces that modulate their effector functions. This review highlights studies that investigate forces from interacting cells, surrounding tissue, and fluid shear forces that T cells face in their journey through the body and how they alter T cell activation. Knowledge from this alternative paradigm could enhance various therapeutics involving T cells.