A review of remote ischemic conditioning as a potential strategy for neural repair poststroke. (22nd December 2022)

• Record Type: Journal Article
• Authors: Yu, Wantong; Ren, Changhong; Ji, Xunming
• Is Part Of: CNS neuroscience & therapeutics. Volume 29:Number 2(2023)
• Page Start: 516
• Page End: 524
• Publication Date: 2022-12-22
• Subjects: ischemic stroke -- remote ischemic conditioning -- repair; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.14064
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Ischemic stroke is one of the major disabling health‐care problem and multiple different approaches are needed to enhance rehabilitation, in which neural repair is the structural basement. Remote ischemic conditioning (RIC) is a strategy to trigger endogenous protect. RIC has been reported to play neuroprotective role in acute stage of stroke, but the effect of RIC on repair process remaining unclear. Several studies have discovered some overlapped mechanisms RIC and neural repair performs. This review provides a hypothesis that RIC is a potential therapeutic strategy on stroke rehabilitation by evaluating the existing evidence and puts forward some remaining questions to clarify and future researches to be performed in the field. Abstract : The figure shows the speculation that chronic RIC may enhance neural repair after ischemic stroke by improving neurogenesis, angiogenesis, axonal regeneration, synaptogenesis and remyelination.