Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect. Issue 12 (9th September 2022)

• Record Type: Journal Article
• Authors: Jiang, Xin; Yan, Nieng; Deng, Dong; Yan, Chuangye
• Other Names: Kikuchi Akira guestEditor.; Chang Zengyi guestEditor.; Gleeson Paul A guestEditor.
• Is Part Of: IUBMB life. Volume 74:Issue 12(2022)
• Page Start: 1180
• Page End: 1199
• Publication Date: 2022-09-09
• Subjects: alternating access -- glucose transporters -- lactate shuttling -- monocarboxylate transporters -- Warburg effect; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.2668
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the "Warburg effect". To accommodate the high glucose demands and to avoid lactate accumulation, the expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are elevated to maintain metabolic homeostasis. Therefore, inhibition of GLUTs and/or MCTs provides potential therapeutic strategies for cancer treatment. Here, we summarize recent advances in the structural characterization of GLUTs and MCTs, providing a comprehensive understanding of their transport and inhibition mechanisms to facilitate further development of anticancer therapies.