A new lactone from mangrove endophytic fungus Aspergillus sp. GXNU-A9. Issue 3 (1st February 2023)

• Record Type: Journal Article
• Authors: Zhang, Wenxiu; Hao, Lili; Qin, Xiaoya; Huang, Jiguo; Yang, Ruiyun; Li, Jun; Huang, Xishan
• Is Part Of: Natural product research. Volume 37:Issue 3(2023)
• Page Start: 417
• Page End: 423
• Publication Date: 2023-02-01
• Subjects: Aspergillus sp. -- mangrove endophytic fungus -- asperlactone A -- anti-inflammatory effects; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1977298
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new lactone, asperlactone A (1 ), and four known lactone derivatives 2 –5 were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. Their structures were elucidated based on high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) datum, extensive nuclear magnetic resonance (NMR) spectroscopic analysis, and comparison with literature data. The structure of 1 was further confirmed by single-crystal X-ray diffraction analysis, and the absolute configuration of 1 was established. Compounds 1 –5 were evaluated for their anti-inflammatory activities against nitric oxide (NO) production, and compounds 1–5 showed moderate inhibitory activities with IC50 values ranging from 15.87 to 30.48 µ M. Graphical abstract: UF0001