Characteristics and prognosis of children with recurrent T-cell acute lymphoblastic leukemia: a long-term follow-up report in China. Issue 14 (6th December 2022)

• Record Type: Journal Article
• Authors: Liu, Xiaoming; Zou, Yao; Zhang, Li; Zhang, Yingchi; Chen, Yumei; Chen, Xiaojuan; Guo, Ye; Yang, Wenyu; Zhu, Xiaofan
• Is Part Of: Leukemia & lymphoma. Volume 63:Issue 14(2022)
• Page Start: 3462
• Page End: 3474
• Publication Date: 2022-12-06
• Subjects: Child -- T-cell acute lymphoblastic leukemia -- recurrence -- long-term follow-up; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2022.2123224
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: This study assessed the relapse characteristics and prognosis of 145 children newly diagnosed with T-cell acute lymphoblastic leukemia (T-ALL). The overall complete response (CR) rate was 91.7% (133/145), and the overall recurrence rate was 31.6% (42/133). The recurrence rate in the intermediate-risk (IR) group and high-risk (HR) group was 15.4% and 47.1%, respectively ( p < 0.001). Patients with young age, early T-cell precursor ALL, central nervous system (CNS) involvement, TCRγ gene rearrangement, karyotypic abnormalities, or absence of TCRβ gene rearrangement ( p < 0.05) tended to relapse. All recurrences occurred within 36 months after diagnosis. The HR group recurred earlier than the IR group ( p = 0.026). The 3-year overall survival (OS) rate was significantly lower in the HR group than in the IR group ( p < 0.001). All relapsed children died within 12 months after recurrence. Early intervention may benefit children with a high risk of recurrence.