Anti-EGFR-Based Therapy in Recurrent or Metastatic HNSCC – What Difference Does it Make?. (2nd January 2023)

• Record Type: Journal Article
• Authors: Eggers, Hendrik; Häbel, Lea; Ganser, Arnold; Grünwald, Viktor; Merten, Roland; Warnecke, Athanasia; Durisin, Martin; Ivanyi, Philipp
• Is Part Of: Cancer investigation. Volume 41:Number 1(2023)
• Page Start: 93
• Page End: 100
• Publication Date: 2023-01-02
• Subjects: Anti-EGFR -- cetuximab -- head and neck cancer -- treatment -- R/M-HNSCC; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2022.2134414
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: Patients with R/M HNSCC treated with palliative first-line therapy at Hannover Medical School between October 2005 and December 2016 have been included to show changes in survival following broad utilization of cetuximab. Treatment periods were defined from 10/2005 to 12/2008 (Period A) and 01/2009 to 12/2016. Overall survival did not improve over time. However, in subgroup analysis cetuximab utilized at any time vs. never showed a significant improve of overall survival (11.3 vs. 6.3 months, HR: 0.55, 95%-CI: 0.4–0.8, p = 0.04). Therefore, this study supports the application of cetuximab in this real-world population.