Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer. (2nd January 2023)

• Record Type: Journal Article
• Authors: Giatromanolaki, Alexandra; Chatzipantelis, Paschalis; Contrafouris, Constantinos A.; Koukourakis, Michael I.
• Is Part Of: Cancer investigation. Volume 41:Number 1(2023)
• Page Start: 48
• Page End: 57
• Publication Date: 2023-01-02
• Subjects: Non-small-cell lung cancer -- tertiary lymphoid structures -- tumor-infiltrating lymphocytes -- prognosis; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2022.2136684
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract: We assessed the presence of 'tertiary lymphoid structures' (TLS) in a series of surgically treated non-small cell lung carcinomas (NSCLC). The TLS-density in the tumor periphery (pTLS) ranged from 0 to 1.8 (median 0.45), while in inner tumor areas (iTLS) ranged from 0 to 1.0 (median 0); ( p < 0.0001). High pTLS-density was linked with early stage of the disease. Glycolysis-related enzyme expression (MCT1, Hexokinase 2) was linked with high pTLS-density ( p < 0.05). High pTLS and iTLS densities were linked with better postoperative prognosis ( p = 0.02 and p = 0.01, respectively). Assessment of TLS is a useful prognostic marker in NSCLC.