Primary and Secondary Hepatic Lymphomas Diagnosed by Image-Guided Fine-Needle Aspiration: A Retrospective Study of Clinical and Cytomorphologic Findings. Issue 1 (1st January 2014)

• Record Type: Journal Article
• Authors: Swadley, Matthew J.; Deliu, Matea; Mosunjac, Marina B.; Gunthel, Clifford J.; Nguyen, Minh Ly T.; Hanley, Krisztina Z.
• Is Part Of: American journal of clinical pathology. Volume 141:Issue 1(2014)
• Page Start: 119
• Page End: 127
• Publication Date: 2014-01-01
• Subjects: Hepatic -- Liver -- Lymphoma -- Hematolymphoid -- Fine-needle aspiration -- HIV -- Primary cytology; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1309/AJCPE58ESCQDZFKX
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To explore the diagnosis of hematolymphoid malignancies of the liver (hepatic lymphoma [HeL]) by image-guided fine-needle aspiration (FNA), which can often be difficult due to a low index of suspicion and nonspecific patient presentations, especially in the rare cases where the liver is the only site of disease (primary HeL [PHeL]). Understanding the clinical setting in which such lesions arise, as well as the cytomorphologic findings, may assist cytopathologists in making an accurate diagnosis and triaging samples for ancillary studies. Methods: In this retrospective study of 32 patients with HeL, the largest such study to our knowledge, we review the clinical and diagnostic features of HeL. Results: HeL and especially PHeL most commonly show a diffuse large B-cell lymphoma phenotype and have a poor prognosis (median survival of seven months). PHeL is strongly associated with human immunodeficiency virus infection (12/16 patients). Conclusions: Image-guided FNA with immediate evaluation is a reliable means to obtain diagnostic material and triage for ancillary tests.