Lasibidoupins A and B, two new compounds from the stems of Lasianthus bidoupensis V.S. Dang & Naiki. Issue 3 (1st February 2023)

• Record Type: Journal Article
• Authors: Pham, Nguyen Kim Tuyen; Nguyen, Thi Diem Huong; Nguyen, Thi Mong Cam; Nguyen, Gia Dinh; Huynh, Cong Doan; Vo, Thi Nga; Nguyen, Thi Quynh Trang; Duong, Thuc Huy; Dang, Van Son; Huynh, Bui Linh Chi; Tran, Thi Ngoc Mai; Nguyen, Tan Phat
• Is Part Of: Natural product research. Volume 37:Issue 3(2023)
• Page Start: 455
• Page End: 461
• Publication Date: 2023-02-01
• Subjects: Lasianthus bidoupensis -- 9, 10-anthraquinone -- 6, 7-benzocoumarin -- lasibidoupin A -- lasibidoupin B -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2021.1979545
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: From the Lasianthus bidoupensis stems, two new compounds, including one new 9, 10-anthraquinone, lasibidoupin A (1 ), and one new 6, 7-benzocoumarin, lasibidoupin B (2 ), together with one known compound, 11- O -methyldamnacanthol (3 ) were isolated using chromatographic method. Their structures were determined by extensive HRMS, and NMR assignments. Compound 3 was reported for the first time from this species. New compounds (1 & 2 ) were tested for the cytotoxicity against three human cancer cell lines (MCF-7, HeLa, and NCI-H460) by SRB assay. As results, 1 & 2 exhibited significant cytotoxic activity against all cancer cell lines (IC50 ranged from 0.058 ± 0.003 to 0.177 ± 0.014 μM). Graphical Abstract: UF0001